Losing the title and regaining it
On July 14, 2007, Margarito lost a unanimous 12 round decision to undefeated challenger Paul Williams, losing his WBO belt. After the bout Margarito heavily disputed the decision, claiming that he had landed the most meaningful punches. Williams, however, landed the most punches (outhitting Margarito by almost a 2-1 ratio, and throwing an average of over 100 punches per round) according to compubox.On April 12, 2008, Margarito engaged in a rematch with Cintron, who had won the IBF welterweight title belt following his loss to Margarito in 2005. In the early rounds, Cintron struck Margarito with several flush power shots to the head, but Margarito remained unhurt and continued to execute a game plan of continuously moving forward and pressuring Cintron. In the sixth round, Margarito landed a liver shot to Cintron's midsection, knocking him out and taking the IBF title. As the referee counted Cintron out, HBO cameras captured Margarito, from a neutral corner, gesturing upward with his arms and urging Cintron to get up so that the two men could continue fighting for a longer period of time.
