Super Bantamweight division
Following his loss to Singsurat, Pacquiao gained weight anew and skipped the super flyweight and bantamweight divisions. This time, Pacquiao went to super bantamweight or junior featherweight division of 122 pounds, where he picked up the WBC Super Bantamweight International Title. He defended this title five times before his chance for a world title fight came. Pacquiao's big break came on June 23, 2001, against former IBF World Super Bantamweight champion Lehlohonolo Ledwaba. Pacquiao stepped into the fight as a late replacement on two weeks' notice but won the fight by technical knockout and won the International Boxing Federation (IBF) Junior Featherweight World Title belt, his second major boxing world title. The bout was held at the MGM Grand Las Vegas, in Las Vegas, Nevada. Pacquiao went on to defend this title four times under head trainer Freddie Roach, owner of the famous Wild Card Gym in West Hollywood.Featherweight division
On November 15, 2003, Pacquiao faced Marco Antonio Barrera at the Alamodome, San Antonio, Texas, in a fight that many consider to have defined his career. Pacquiao, who was fighting at featherweight for the first time, brought his power with him and defeated Barrera via technical knockout in the eleventh round and won The Ring Featherweight World Title (as well as the lineal featherweight champion), making him the first Filipino and Asian to become a three-division world champion, a fighter who won world titles in three different weight divisions. He defended the title twice before relinquishing it in 2005.Six months after the fight, Pacquiao went on to challenge Juan Manuel Márquez, who at the time held both the World Boxing Association (WBA) and International Boxing Federation (IBF) Featherweight World Titles. The fight took place at the MGM Grand Las Vegas, on May 8, 2004, and after twelve rounds the bout was scored a draw, which proved to be a controversial decision that outraged both camps.
In the first round, Márquez was caught cold, as he was knocked down three times by Pacquiao. However, Márquez showed great heart to recover from the early knockdowns, and went on to win the majority of rounds thereafter. This was largely due to Márquez's counterpunch style, which he managed to effectively utilize against the aggressive style of Pacquiao. At the end of a very close fight, the final scores were 115–110 for Márquez, 115–110 for Pacquiao, and 113–113. One of the judges (who scored the bout 113–113) later admitted to making an error on the scorecards, because he had scored the first round as "10–7" in favor of Pacquiao instead of the standard "10–6" for a three-knockdown round. In fact, the fight should be scored as split decision in favor of Pacquiao. Consequently, both parties felt they had done enough to win the fight.